Basic science, screening, prevention and prenatal diagnosis of Haemoglobinopathy

This module will teach the structure and genetic control of haemoglobin synthesis, iron metabolism, epidemiology and screening, prevention, and prenatal diagnosis of haemoglobinopathy. The student will also learn use of statistics to evaluate experimental and clinical data and the principles of experimental design and clear data presentation. Teaching will be based on a problem solving approach using a variety of computer programmes.

This introductory module will establish core knowledge on which the student can subsequently develop a firm understanding of haemoglobinopathy. It will introduce the student to a wide range of processes enabling the student to put into context those technologies and pathophysiologies which are commonly observed in haemoglobinopathy.

On completion the students should have a comprehensive understanding of
1. The structure and regulation of haemoglobin synthesis
2. The epidemiology of haemoglobinopathy
3. Prevention and screening
4. Counselling and prenatal diagnosis of haemoglobinopathy
5. Pre implantation genetic diagnosis and non-invasive methods of diagnosis
6. Research Methods and Ethics